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Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1.
Eggler AL, Small E, Hannink M, Mesecar AD.
Biochem J. 2009 Jul 29;422(1):171-80.
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Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.
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