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    Prostate Cancer Prostatic Dis. 2009;12(3):296-300. Epub 2009 Jun 2.

    PTGS2-899G>C and prostate cancer risk: a population-based nested case-control study (ProtecT) and a systematic review with meta-analysis.

    Murad A, Lewis SJ, Smith GD, Collin SM, Chen L, Hamdy FC, Neal DE, Donovan J, Martin RM.

    Source

    Department of Social Medicine, University of Bristol, Bristol, UK.

    Abstract

    Prostaglandin endoperoxidase synthase 2 is a key regulator of inflammation and may play a role in prostate carcinogenesis. The polymorphism, -899G>C (rs20417), alters a transcription factor-binding site and is associated with a reduced risk of colorectal adenoma. We tested the hypothesis that rs20417 may influence prostate cancer risk, using a large case-control study (n(cases)=1608, n(controls)=3058). We found no evidence that rs20417 alters prostate cancer risk (odds ratio (OR(CC & GC v GG)=1.05, 95% confidence interval (CI)=0.91-1.20). A meta-analysis of three studies also found little evidence that rs20417 alters risk (pooled OR(CC & GC v GG)=1.04, 95% CI=0.93-1.17), making it unlikely that rs20417 contributes in any major way to prostate cancer aetiology.

    PMID:
    19488068
    [PubMed - indexed for MEDLINE]

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