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Ann Surg Oncol. 2009 Aug;16(8):2264-9. doi: 10.1245/s10434-009-0534-1. Epub 2009 May 30.

Management of intraductal papillomas of the breast: an analysis of 129 cases and their outcome.

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  • 1Department of Surgery, Brigham and Women's Hospital and the Dana Farber Cancer Institute, Boston, MA, USA.



The management of intraductal papillomas of the breast has been controversial; some advocate surgical excision of all lesions despite benign pathologic features, whereas others excise only those specimens with atypia.


We conducted a retrospective review of 129 core-biopsy-proven papillomas of the breast with atypia (n = 43) and without atypia (n = 86) and determined the rate of missed carcinoma in surgically excised specimen in each group.


Carcinoma was found in 22.5% of the surgically excised specimens in the atypia group (9/40) and in 3% of the surgically excised specimens in the no atypia group (1/29).


Our findings confirm the practice that papillomas with atypical features should be excised, and suggest that in patients with adequate follow-up, benign papillomas may be managed conservatively.

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