The dispersion and loss in microstructured fibers are studied using a full-vectorial compact-2D finite-difference method in frequency-domain. This method solves a standard eigen-value problem from the Maxwell's equations directly and obtains complex propagation constants of the modes using anisotropic perfectly matched layers. A dielectric constant averaging technique using Ampere's law across the curved media interface is presented. Both the real and the imaginary parts of the complex propagation constant can be obtained with a high accuracy and fast convergence. Material loss, dispersion and spurious modes are also discussed.