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Nat Chem Biol. 2009 Jul;5(7):479-83. doi: 10.1038/nchembio.180. Epub 2009 May 31.

Quantifying biogenic bias in screening libraries.

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  • 1Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, USA.

Abstract

In lead discovery, libraries of 10(6) molecules are screened for biological activity. Given the over 10(60) drug-like molecules thought possible, such screens might never succeed. The fact that they do, even occasionally, implies a biased selection of library molecules. We have developed a method to quantify the bias in screening libraries toward biogenic molecules. With this approach, we consider what is missing from screening libraries and how they can be optimized.

PMID:
19483698
[PubMed - indexed for MEDLINE]
PMCID:
PMC2783405
Free PMC Article

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