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Pediatr Infect Dis J. 2009 Jun;28(6):539-41. doi: 10.1097/INF.0b013e318193ef38.

The high rate of adverse drug events in children receiving prolonged outpatient parenteral antibiotic therapy for osteomyelitis.

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  • 1Department of Pediatrics, State University of New York, Buffalo, NY, USA. hfaden@upa.chob.edu


Forty-five children treated with 82 courses of 15 different antibiotics over 344 weeks during outpatient parenteral antibiotic therapy were evaluated for adverse drug events (ADE). Fifty-one percent of the courses had an associated ADE and 32.5% of the antibiotic courses were discontinued because of ADE. Vancomycin had the highest ADE rate at 85.7% and ceftriaxone had the highest ADE-related discontinuation rate at 66.7%. Cefazolin had the lowest rate of ADE and ADE-related discontinuation rates at 0% for both.

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