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Mult Scler. 2009 Jun;15(6):771-4. doi: 10.1177/1352458509104588.

Protective role of the HLA-A*02 allele in Portuguese patients with multiple sclerosis.

Author information

  • 1Departamento de Neurologia, Centro Hospitalar do Porto-Hospital de Santo António, Porto, Portugal. anadmsilva@yahoo.com

Abstract

BACKGROUND:

Multiple sclerosis (MS) is associated with human leukocyte antigen (HLA) HLA-DRB1*15. Recent evidence that CD8 T cells are implicated in MS suggests that HLA class I may also contribute. An association of HLA-A*02 and A*03 alleles has been described.

OBJECTIVES:

We examined the influence of HLA-A*02 and HLA-A*03 in Portuguese patients with MS, independently of HLA-DRB1*15 using a logistic regression model.

CONCLUSIONS:

DRB1*15 increased the risk of developing MS and HLA-A*02 decreased the risk. A*03 had no effect. To analyze if HLA-A*02 association was independent from DRB1*15, an interaction between these two alleles was introduced in the model; no significant interaction was found.

PMID:
19482867
[PubMed - indexed for MEDLINE]
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