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Mult Scler. 2009 Jun;15(6):678-86. doi: 10.1177/1352458509103611.

T2 hypointensity in the deep gray matter of patients with benign multiple sclerosis.

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  • 1Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy.

Abstract

BACKGROUND:

Gray matter (GM) magnetic resonance imaging (MRI) T2 hypointensity, a putative marker of iron deposition, commonly occurs in multiple sclerosis (MS). However, GM T2 hypointensity in benign MS (BMS) has not yet been characterized.

OBJECTIVE:

To determine the presence of deep GM T2 hypointensity in BMS, compare it to secondary progressive (SP) MS and assess its association with clinical and diffusion tensor (DT) MRI measures.

METHODS:

Thirty-five cognitively unimpaired BMS, 26 SPMS patients, and 25 healthy controls were analyzed for normalized T2-intensity in the basal ganglia and thalamus, global T2 hyperintense lesion volume, global atrophy, and white matter and GM DT metrics.

RESULTS:

BMS and SPMS patients showed deep GM T2 hypointensity compared with controls. T2 hypointensity was similar in both MS subgroups and moderately correlated (r = -0.45 to 0.42) with DT MRI metrics. GM T2 hypointensity in BMS showed a weak to moderate correlation (r = -0.44 to -0.35) with disability.

CONCLUSIONS:

GM in BMS is not spared from structural change including iron deposition. However, while T2 hypointensity is related to global tissue disruption reflected in DT MRI, the expression of benign versus non-benign MS is likely related to other factors.

PMID:
19482861
[PubMed - indexed for MEDLINE]
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