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Mol Cell. 2009 May 14;34(4):397-9. doi: 10.1016/j.molcel.2009.05.004.

Keys to open chromatin for transcription activation: FACT and Asf1.

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  • 1Functional Genomics Department, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR 7104, INSERM U 964, Université de Strasbourg, ILLKIRCH, France.


In this issue of Molecular Cell, Takahata et al. (2009) dissect the mechanisms preceding transcription initiation, revealing a wave of nucleosome eviction, which spreads from distant cis-regulatory elements to promoters and which requires the activity of histone chaperones, FACT and Asf1.

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