Science. 1991 Oct 25;254(5031):579-80.

Cloning of a serotonin transporter affected by antidepressants.

Source

Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, MD 20892.

Abstract

A complementary DNA clone for a serotonin (5HT) transporter has been isolated from rat basophilic leukemia cells. The complementary DNA sequence predicts a 653-amino acid protein with 12 to 13 putative transmembrane domains. The 5HT transporter has significant homology to the gamma-aminobutyric acid, dopamine, and norepinephrine transporters. Uptake by CV-1 cells expressing the transporter complementary DNA resembles 5HT uptake by platelets and brain synaptosomes; it is sensitive to antidepressants, amphetamine derivatives, and cocaine.

PMID:: 1948036; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Medical

Antidepressants - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization. [Proc Natl Acad Sci U S A. 1993]
Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization.
Ramamoorthy S, Bauman AL, Moore KR, Han H, Yang-Feng T, Chang AS, Ganapathy V, Blakely RD. Proc Natl Acad Sci U S A. 1993 Mar 15; 90(6):2542-6.
Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter. [Nature. 1991]
Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter.
Pacholczyk T, Blakely RD, Amara SG. Nature. 1991 Mar 28; 350(6316):350-4.
Cloning, expression, and localization of a chloride-facilitated, cocaine-sensitive serotonin transporter from Drosophila melanogaster. [Proc Natl Acad Sci U S A. 1994]
Cloning, expression, and localization of a chloride-facilitated, cocaine-sensitive serotonin transporter from Drosophila melanogaster.
Demchyshyn LL, Pristupa ZB, Sugamori KS, Barker EL, Blakely RD, Wolfgang WJ, Forte MA, Niznik HB. Proc Natl Acad Sci U S A. 1994 May 24; 91(11):5158-62.
Review Drug targets in the embryo. Studies on the cocaine- and antidepressant-sensitive serotonin transporter. [Ann N Y Acad Sci. 1996]
Review Drug targets in the embryo. Studies on the cocaine- and antidepressant-sensitive serotonin transporter.
Schroeter S, Blakely RD. Ann N Y Acad Sci. 1996 Oct 31; 801:239-55.
Review Transporter explosion: update on uptake. [Trends Pharmacol Sci. 1992]
Review Transporter explosion: update on uptake.
Uhl GR, Hartig PR. Trends Pharmacol Sci. 1992 Dec; 13(12):421-5.

See reviews... See all...

Cited by 46 PubMed Central articles

Dopamine transport by the serotonin transporter: a mechanistically distinct mode of substrate translocation. [J Neurosci. 2011]
Dopamine transport by the serotonin transporter: a mechanistically distinct mode of substrate translocation.
Larsen MB, Sonders MS, Mortensen OV, Larson GA, Zahniser NR, Amara SG. J Neurosci. 2011 Apr 27; 31(17):6605-15.
Review Communication between 5-HT and small GTPases. [Curr Opin Pharmacol. 2011]
Review Communication between 5-HT and small GTPases.
Mercado CP, Ziu E, Kilic F. Curr Opin Pharmacol. 2011 Feb; 11(1):23-8. Epub 2011 Feb 12.
Brain serotonergic circuitries. [Dialogues Clin Neurosci. 2010]
Brain serotonergic circuitries.
Charnay Y, Léger L. Dialogues Clin Neurosci. 2010; 12(4):471-87.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide
Primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Cloning of a serotonin transporter affected by antidepressants.
Cloning of a serotonin transporter affected by antidepressants.
Science. 1991 Oct 25 ;254(5031):579-80.

PubMed
[Association between adiposity measures, demographic and biochemical variables w...
[Association between adiposity measures, demographic and biochemical variables with C-reactive protein serum levels in rural population].
Arch Latinoam Nutr. 2009 Mar ;59(1):54-60.

PubMed
Women's lifestyle and the risk of breast tumors.
Women's lifestyle and the risk of breast tumors.
Eur J Gynaecol Oncol. 2009 ;30(2):186-9.

PubMed
Identifying risk factors for racial disparities in diabetes outcomes: the transl...
Identifying risk factors for racial disparities in diabetes outcomes: the translating research into action for diabetes study.
Med Care. 2009 Jun ;47(6):700-6.

PubMed
Gene expression profiling during rat mammary carcinogenesis induced by 7,12-dime...
Gene expression profiling during rat mammary carcinogenesis induced by 7,12-dimethylbenz[a]anthracene.
Int J Cancer. 2009 Sep 15 ;125(6):1285-97.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Cloning of a serotonin transporter affected by antidepressants.

Source

Abstract

Publication Types, MeSH Terms, Substances, Secondary Source ID

Publication Types

MeSH Terms

Substances

Secondary Source ID

LinkOut - more resources

Full Text Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Cited by 46 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information