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Science. 1991 Oct 25;254(5031):578-9.

Cloning and expression of a cocaine-sensitive rat dopamine transporter.

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  • 1Yale University, New Haven, CT 06510.


The action of dopamine and other monoamine neurotransmitters at synapses is terminated predominantly by high-affinity reuptake into presynaptic terminals by specific sodium-dependent neurotransmitter transport proteins. A complementary DNA encoding a rat dopamine transporter has been isolated that exhibits high sequence similarity with the previously cloned norepinephrine and gamma-aminobutyric acid transporters. Transient expression of the complementary DNA in HeLa cells confirms the cocaine sensitivity of this transporter.

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