Abstract
Biodiversity is a major resource for identification of new molecules with specific therapeutic activities. To identify such an active resource, high throughput screening (HTS) of the extracts prepared from such diversity are examined on specific functional assays. Based on such HTS studies and bioactivity-based fractionation, we have isolated ergoflavin, a pigment from an endophytic fungus, growing on the leaves of an Indian medicinal plant Mimosops elengi (bakul). We report here the isolation, structure elucidation, and biological properties of this compound, which showed good anti-inflammatory and anticancer activities.
MeSH terms
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / isolation & purification
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Anti-Inflammatory Agents / pharmacology*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology*
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Ascomycota / chemistry*
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Ascomycota / growth & development
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Ascomycota / metabolism
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Cell Line, Tumor
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Chromones / chemistry
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Chromones / isolation & purification
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Chromones / pharmacology*
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Drug Screening Assays, Antitumor
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Humans
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Interleukin-6 / metabolism
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Lactones / chemistry
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Lactones / isolation & purification
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Lactones / pharmacology*
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Mimusops / microbiology
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Plant Leaves / microbiology
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Tumor Necrosis Factor-alpha / metabolism
Substances
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Anti-Inflammatory Agents
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Antineoplastic Agents
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Chromones
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Interleukin-6
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Lactones
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Tumor Necrosis Factor-alpha
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ergoflavin