Curr Opin Mol Ther. 2009 Jun;11(3):292-8.

MicroRNA and stem cell regulation.

Source

Life Technologies, Molecular Biology Systems Division, Foster City, CA 94404, USA.

Abstract

Stem cells and microRNAs (miRNAs) represent two fast-developing frontiers of biological research. Stem cells function in embryonic development and tissue maintenance and are characterized by two fundamental properties: self-renewal and multipotency. Within many types of cancers, a small population of cells possesses stem cell-like characteristics. These cancer stem cells (CSCs) have been hypothesized to represent the disease-propagating and drug-resisting cell population. An increased understanding of the biology of stem cells and CSCs offers potential in the development of regenerative medicine and treatments for oncological disease. miRNAs are emerging as important regulators of post-transcriptional gene regulation, and have been demonstrated to be an integral component in stem cell regulation. This article reviews recent advances in the understanding of the roles of miRNAs in regulating various stem cell types, including embryonic stem cells, adult stem cells and CSCs.

PMID:: 19479662; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

MicroRNAs

LinkOut - more resources

Medical

Stem Cells - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Review MicroRNAs in embryonic stem cells. [J Cell Physiol. 2009]
Review MicroRNAs in embryonic stem cells.
Wang Y, Keys DN, Au-Young JK, Chen C. J Cell Physiol. 2009 Feb; 218(2):251-5.
Review microRNA and stem cell function. [Cell Tissue Res. 2008]
Review microRNA and stem cell function.
Hatfield S, Ruohola-Baker H. Cell Tissue Res. 2008 Jan; 331(1):57-66. Epub 2007 Nov 7.
Review Embryonic stem cell microRNAs: defining factors in induced pluripotent (iPS) and cancer (CSC) stem cells? [Curr Stem Cell Res Ther. 2009]
Review Embryonic stem cell microRNAs: defining factors in induced pluripotent (iPS) and cancer (CSC) stem cells?
Gunaratne PH. Curr Stem Cell Res Ther. 2009 Sep; 4(3):168-77.
Multipotent adult germline stem cells and embryonic stem cells have similar microRNA profiles. [Mol Hum Reprod. 2008]
Multipotent adult germline stem cells and embryonic stem cells have similar microRNA profiles.
Zovoilis A, Nolte J, Drusenheimer N, Zechner U, Hada H, Guan K, Hasenfuss G, Nayernia K, Engel W. Mol Hum Reprod. 2008 Sep; 14(9):521-9. Epub 2008 Aug 12.
Review [miRNAs play an essential role in stem cell self-renewal and differentiation]. [Yi Chuan. 2009]
Review [miRNAs play an essential role in stem cell self-renewal and differentiation].
An Y, An TZ, Teng CB. Yi Chuan. 2009 Feb; 31(2):115-22.

See reviews... See all...

Cited by 8 PubMed Central articles

MicroRNA profiling during cardiomyocyte-specific differentiation of murine embryonic stem cells based on two different miRNA array platforms. [PLoS One. 2011]
MicroRNA profiling during cardiomyocyte-specific differentiation of murine embryonic stem cells based on two different miRNA array platforms.
Gan L, Schwengberg S, Denecke B. PLoS One. 2011; 6(10):e25809. Epub 2011 Oct 3.
Review MicroRNAs in rhabdomyosarcoma: pathogenetic implications and translational potentiality. [Mol Cancer. 2011]
Review MicroRNAs in rhabdomyosarcoma: pathogenetic implications and translational potentiality.
Rota R, Ciarapica R, Giordano A, Miele L, Locatelli F. Mol Cancer. 2011 Sep 24; 10:120. Epub 2011 Sep 24.
Differences in the properties and mirna expression profiles between side populations from hepatic cancer cells and normal liver cells. [PLoS One. 2011]
Differences in the properties and mirna expression profiles between side populations from hepatic cancer cells and normal liver cells.
Liu WH, Tao KS, You N, Liu ZC, Zhang HT, Dou KF. PLoS One. 2011; 6(8):e23311. Epub 2011 Aug 3.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

MicroRNA and stem cell regulation.
MicroRNA and stem cell regulation.
Curr Opin Mol Ther. 2009 Jun ;11(3):292-8.

PubMed
CD52 expression in peripheral T-cell lymphomas determined by combined immunophen...
CD52 expression in peripheral T-cell lymphomas determined by combined immunophenotyping using tumor cell specific T-cell receptor antibodies.
Leuk Lymphoma. 2009 Jun ;50(6):1010-6.

PubMed
Protective and therapeutic effects of resveratrol on acetic acid-induced gastric...
Protective and therapeutic effects of resveratrol on acetic acid-induced gastric ulcer.
Free Radic Res. 2009 Jun ;43(6):594-603.

PubMed
Development, standardisation and pilot testing of an online fatigue self-managem...
Development, standardisation and pilot testing of an online fatigue self-management program.
Disabil Rehabil. 2009 ;31(21):1762-72.

PubMed
Relationship between participation in life situations and life satisfaction in p...
Relationship between participation in life situations and life satisfaction in persons with late effects of polio.
Disabil Rehabil. 2009 ;31(19):1592-7.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: