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Curr Treat Options Oncol. 2008 Dec;9(4-6):400-7. doi: 10.1007/s11864-009-0103-7. Epub 2009 May 29.

Treatment options in metastatic squamous cell carcinoma of the anal canal.

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  • 1The Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 426, Houston, TX 77030, USA. ceng@mdanderson.org

Abstract

Squamous cell carcinoma of the anal canal is a rare malignancy that is often cured with the combined modality therapy of chemoradiation. Yet, a minority of patients will develop distant metastatic disease, an area of oncology in which a universally accepted approach has not been determined. Consideration of platinum-based systemic chemotherapy is commonly provided for palliation with the optimal duration of therapy being largely unknown; the role of biologics and/or surgical resection of metastatic disease are anecdotal. Patients with no contraindications to systemic chemotherapy should be treated aggressively with consideration of multidisciplinary management if appropriate. Here, we present a summary of the existing literature in the treatment of metastatic anal carcinoma in the hopes of providing insight and potential treatment alternatives for the practicing physician.

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