Send to:

Choose Destination
See comment in PubMed Commons below
Nutrition. 2009 Sep;25(9):940-6. doi: 10.1016/j.nut.2009.01.017. Epub 2009 May 28.

Effects of dietary polyamines at physiologic doses in early-weaned piglets.

Author information

  • 1Department of Physiology, Faculty of Biology, University of Murcia, Murcia, Spain.



Polyamines are essential for many cell functions, and they form part of the composition of maternal milk; despite this, their addition to infant formulas is currently under evaluation. The aim of the present study was to evaluate the effects of milk formulas designed to resemble sow milk supplemented with polyamines at maternal physiologic milk doses on the gut maturation of early-weaned piglets.


We fed 30 newborn piglets with maternal milk (n=10), a control milk formula (n=10), or a milk formula supplemented with polyamines (5 nmol/mL of spermine and 20 nmol/mL of spermidine, n=10) for 13 d (day 2 after birth through day 15). Several growth and intestinal development parameters were measured.


The piglets fed the formula containing polyamine at physiologic doses showed significantly increased crypt depth in the small intestine compared with those fed with the control formula. Villus length was correlated to crypt depth. Although there were no differences in the disaccharidase activities between the animals fed the two formulas, alkaline phosphatase and gamma-glutamyl transferase activities tended to be higher in the jejunum of those fed the polyamine-supplemented diet. Dietary polyamines did not significantly modify the gut mucosal concentrations of putrescine, spermine, or spermidine.


Milk formulas supplemented with polyamines at maternal milk physiologic doses slightly enhanced gut growth and maturation in neonatal piglets.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk