Int Urol Nephrol. 2010 Mar;42(1):95-102. Epub 2009 May 28.

Up-regulation of microRNA in bladder tumor tissue is not common.

Wang G, Zhang H, He H, Tong W, Wang B, Liao G, Chen Z, Du C.

Source

Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Jie Fang Road, Hangzhou, Zhejiang, People's Republic of China. gwang59@gmail.com

Abstract

MicroRNAs (miRNAs) have recently been shown to down-regulate gene expression by targeting mRNA translation and to play a critical role in tumorigenesis; how they regulate bladder tumor development, particularly in patients, is, however, poorly understood. The difference in miRNA expression in a bladder tumor compared with healthy tissue from the same patients was examined using microRNA arrays in seven patients. Here, we showed that up-regulation of miRNA was not commonly found in this limited number of patients, and four miRNAs (miR-26a, miR-29c, miR-30c, miR-30e-5p) were down-regulated as a common marker in patients with a 1-3 grade of disease. Our data suggest that instead of up-regulation of carcinogenic miRNAs, loss of regulation of these miRNA may be critical for bladder tumor development in patients.

PMID:: 19475496; [PubMed - indexed for MEDLINE]

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Research Support, Non-U.S. Gov't

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MicroRNAs

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