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Haemophilia. 2009 Jul;15(4):952-8. doi: 10.1111/j.1365-2516.2009.02020.x. Epub 2009 Apr 7.

Treatment of ischaemic heart disease in haemophilia patients: an institutional guideline.

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  • 1Van Creveldkliniek/Department of Haematology, University Medical Center Utrecht, Heidelberglaan 100, PO Box 85500, Utrecht 3508 GA, The Netherlands. r.schutgens@umcutrecht.nl


Since the introduction of clotting factor concentrates, life expectancy of haemophilia patients is increasing and now approaches that of the general male population. Increasingly, haemophilia patients are confronted with age-related co-morbidity, including ischaemic cardiovascular disease. Treatment of stable angina pectoris and the acute coronary syndrome with antithrombotic therapy and percutaneous coronary intervention in haemophilia patients is feasible, but requires a tight co-operation between all specialists involved. As evidence-based guidelines are lacking, we developed a protocol on how we will treat haemophilia patients with ischaemic heart disease.

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