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Eur J Neurol. 2009 Sep;16(9):990-7. doi: 10.1111/j.1468-1331.2009.02618.x. Epub 2009 Mar 31.

Total daily sleep duration and the risk of dementia: a prospective population-based study.

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  • 1Department of Neurology, University Hospital '12 de Octubre', Madrid, Spain. jbenitol@meditex.es

Abstract

BACKGROUND AND PURPOSE:

We determined in a population-based study whether sleep duration was associated with an increased risk of incident dementia.

METHODS:

In a population-based study in central Spain, participants were evaluated at baseline and 3 years later. Baseline demographic variables were recorded and participants indicated their daily sleep duration as the sum of night-time sleep and daytime napping. The average daily total sleep duration was grouped into five categories: < or = 5 (short sleepers), 6, 7 (reference), 8, and > or = 9 h (long sleepers). We identified all cases with incident dementia, diagnosed using DSM-IV criteria.

RESULTS:

Three thousand two hundred eighty six participants with baseline information about sleep duration had a median duration of follow-up of 3.2 years. There were 140 incident cases of dementia. The relative risks (RR) for short sleepers and for long sleepers were 2.36 (95% CI = 1.07-5.21, P = 0.03) and 2.40 (95% CI = 1.20-4.81, P = 0.01), respectively. After adjustment for potential confounders, the RR was only marginally increased for short sleepers (1.87, 95% CI = 0.85-4.15, P = 0.12) but remained increased for long sleepers (2.18; 95% CI = 1.09-4.37, P = 0.03).

CONCLUSIONS:

Prolonged sleep duration (night-time sleep and daytime napping) may be associated with an increased risk of dementia.

PMID:
19473367
[PubMed - indexed for MEDLINE]
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