Some of these are direct targets through binding; others are affected indirectly. The reported effective concentrations, in IC50, Ki. (inhibition constant) or Kd (dissociation constant) are shown in μM. All these are from studies in vitro. When two values are given, the first value is from cell-free systems and the second value is from studies in cell lines. 67LR, 67 kDa laminin receptor; CDK, cyclin-dependent kinase; DNMT, DNA methyltransferase; EGFR, epidermal growth factor receptor receptor; GRP78, glucose-regulated protein 78kDa; HGFR, hepatocyte growth factor receptor; IGF1R, insulin-like growth factor 1 receptor; MMP, matrix metalloproteinase; ROS, reactive oxygen species; VEGFA, vascular endothelial growth factor A.