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Med Hypotheses. 2009 Nov;73(5):799-801. doi: 10.1016/j.mehy.2009.04.013. Epub 2009 May 20.

Psychosis may be associated with toxoplasmosis.

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  • 1Department of Microbiology and Immunology, College of Basic Medical Sciences, Zhengzhou University, 100 Science Road, Zhengzhou, Henan 450001, PR China.


Many parasites induce characteristic changes in their host. The effect of Toxoplasma gondii infection on the cerebrum and neuropsychiatric patients has been increasingly emphasized in recent years. T. gondii has a high affinity for brain tissue where tachyzoites may form tissue cysts and persist for a life long time. Some psychiatric symptoms such as schizophrenia and mental retardation may be induced by the infection of T. gondii. Furthermore, experiments demonstrated that some antipsychotics and mood stabilizers used to treat psychosis displayed the function of inhibiting T. gondii replication. Investigations from various regions in China in psychotic patients support the hypotheses that psychosis may be linked to T. gondii infection.

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