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J Ethnopharmacol. 2009 Jul 30;124(3):493-8. doi: 10.1016/j.jep.2009.05.017. Epub 2009 May 23.

Immunomodulatory activity of the seeds of Plantago asiatica L.

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  • 1State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi 330047, China.

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE:

The seeds of Plantago asiatica L. were often used as a traditional Chinese medicine for some immunologically weak patients suffering from chronic illness. These uses could be related to immunomodulatory properties of the plant.

AIM OF THE STUDY:

In this study, effects of extract of the seeds of Plantago asiatica L. (ES-PL) were investigated on the maturation of dendritic cells (DCs), which play significant role in primary immune system.

MATERIALS AND METHODS:

The phenotypes of DCs were analyzed by using flow cytometry while phagocytosis was assessed by the uptake of FITC-dextran. Antigen presenting ability to allogeneically naïve or syngeneically primed T lymphocytes was examined by the lymphocyte proliferation of mixed lymphocyte reaction (MLR). In addition, the level of chemokine receptor CCR7 mRNA was determined by RT-PCR.

RESULTS:

DCs treated with ES-PL expressed higher levels of MHC class II molecules and major costimulatory molecules such as CD80 and CD86. Functional maturation of DCs treated with ES-PL was confirmed by decreased mannose receptor-mediated endocytosis and increased antigen presenting abilities to allogeneically naïve or syngeneically primed T lymphocytes. The CCR7 mRNA expression in DCs treated with ES-PL was also enhanced.

CONCLUSIONS:

These results indicated that ES-PL could induce the maturation of murine DCs.

PMID:
19467312
[PubMed - indexed for MEDLINE]
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