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J Am Acad Child Adolesc Psychiatry. 2009 Jul;48(7):703-10. doi: 10.1097/CHI.0b013e3181a56606.

Subthreshold depressive disorder in adolescents: predictors of escalation to full-syndrome depressive disorders.

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  • 1Department of Psychology, State University of New York-Stony Brook, Stony Brook, NY 11794-2500, USA. daniel.klein@stonybrook.edu

Abstract

OBJECTIVES:

Subthreshold depressive disorder is one of the best established risk factors for the onset of full-syndrome depressive disorders. However, many youths with subthreshold depressive disorder do not develop full-syndrome depression. We examined predictors of escalation to full-syndrome depressive disorders in a community sample of 225 adolescents with subthreshold depressive disorder.

METHOD:

Criteria for subthreshold depressive disorder were an episode of depressed mood or loss of interest or pleasure lasting at least 1 week and at least two of the seven other DSM-IV-associated symptoms for major depression. Participants were assessed four times from mid-adolescence to age 30 years using semistructured diagnostic interviews.

RESULTS:

The estimated risk for escalation to full-syndrome depressive disorders was 67%. Five variables accounted for unique variance in predicting escalation: severity of depressive symptoms, medical conditions/symptoms, history of suicidal ideation, history of anxiety disorder, and familial loading for depression. Adolescents with three or more risk factors had an estimated 90% chance of escalating to full-syndrome depressive disorder, compared with 47% of adolescents with fewer than three risk factors.

CONCLUSIONS:

These data may be useful in identifying a subgroup of youths with subthreshold depressive disorder who are at especially high risk for escalating to full-syndrome depressive disorders.

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