DNA Repair (Amst). 2009 Sep 2;8(9):1127-38. Epub 2009 May 22.

DNA double-strand breaks in meiosis: checking their formation, processing and repair.

Longhese MP, Bonetti D, Guerini I, Manfrini N, Clerici M.

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Dipartimento di Biotecnologie e Bioscienze, Università di Milano-Bicocca, P.zza della Scienza 2, 20126 Milan, Italy. mariapia.longhese@unimib.it

Abstract

DNA double-strand breaks (DSBs) are highly hazardous for genome integrity, but meiotic cells deliberately introduce them into their genome in order to initiate homologous recombination, which ensures proper homologous chromosome segregation. To minimize the risk of deleterious effects, meiotic DSB formation, processing and repair are tightly regulated in order to occur only at the right time and place. Furthermore, a highly conserved signal-transduction pathway, called meiotic recombination checkpoint, coordinates DSB repair with meiotic progression and promotes meiotic recombination.

PMID:: 19464965; [PubMed - indexed for MEDLINE]

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Saccharomyces cerevisiae Proteins

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