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Am J Ophthalmol. 2009 Aug;148(2):186-191.e2. doi: 10.1016/j.ajo.2009.03.029. Epub 2009 May 23.

Neuroprotection: extrapolating from neurologic diseases to the eye.

Author information

  • 1Department of Ophthalmology, University of Auckland Medical School, Auckland, New Zealand. helendm@gmail.com

Abstract

PURPOSE:

To review the current status of neuroprotection in ophthalmic disease.

DESIGN:

Perspective.

METHODS:

Published and unpublished data on neuroprotection in neurologic and ophthalmologic diseases were reviewed and interpreted.

RESULTS:

Almost all clinical studies of neuroprotection in neurologic and ophthalmologic disease so far have failed to show efficacy, despite encouraging preclinical studies.

CONCLUSIONS:

Achievement of consensus on how to design and execute translational research in neuroprotection in ophthalmic disease would optimize the use of resources and would hasten the development and approval of effective neuroprotective agents.

PMID:
19464671
[PubMed - indexed for MEDLINE]
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