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Hematol Oncol Clin North Am. 2009 Jun;23(3):383-95, vii. doi: 10.1016/j.hoc.2009.03.010.

Melanoma epidemiology.

Author information

  • Human Genetics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Room 7122, Bethesda, MD 20892-7236, USA. tuckerp@mail.nih.gov

Abstract

Melanoma is a complex, heterogeneous cancer that continues to increase in incidence. Multiple studies have consistently identified major host and environmental risk factors for melanoma. Nevi, particularly dysplastic nevi, confer much higher risks than most pigmentary characteristics. Ultraviolet radiation exposure is the predominant environmental risk factor for melanoma. Recently, both rare high risk susceptibility genes and common polymorphic genes contributing to melanoma risk have been identified.

PMID:
19464592
[PubMed - indexed for MEDLINE]
PMCID:
PMC3234163
Free PMC Article
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