Proc Natl Acad Sci U S A. 1991 Nov 1;88(21):9690-4.

Amino acid sequence of Fel dI, the major allergen of the domestic cat: protein sequence analysis and cDNA cloning.

Morgenstern JP, Griffith IJ, Brauer AW, Rogers BL, Bond JF, Chapman MD, Kuo MC.

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ImmuLogic Pharmaceutical Corp., Cambridge, MA 02139.

Abstract

The complete primary structure of Fel dI (International Union of Immunological Societies nomenclature), the major allergen produced by the domestic cat, Felis domesticus, was determined by protein sequence analysis and cDNA cloning. Protein sequencing of Fel dI from an immunoaffinity-purified extract of house dust revealed that the allergen is composed of two polypeptide chains. Degenerate oligonucleotides derived from the protein sequence were used in polymerase chain reaction amplification of cat salivary gland cDNA to demonstrate that the two chains are encoded by different genes. Chain 1 of Fel dI shares amino acid homology with rabbit uteroglobin, while chain 2 is a glycoprotein with N-linked oligosaccharides.

PMID:: 1946388; [PubMed - indexed for MEDLINE]
PMCID:: PMC52784

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Cited by 8 PubMed Central articles

Glutaraldehyde-Modified Recombinant Fel d 1: A Hypoallergen With Negligible Biological Activity But Retained Immunogenicity. [World Allergy Organ J. 2011]
Glutaraldehyde-Modified Recombinant Fel d 1: A Hypoallergen With Negligible Biological Activity But Retained Immunogenicity.
Versteeg SA, Bulder I, Himly M, van Capel TM, van den Hout R, Koppelman SJ, de Jong EC, Ferreira F, van Ree R. World Allergy Organ J. 2011 Jul; 4(7):113-9. Epub 2011 Jul 14.
Rapid bursts of androgen-binding protein (Abp) gene duplication occurred independently in diverse mammals. [BMC Evol Biol. 2008]
Rapid bursts of androgen-binding protein (Abp) gene duplication occurred independently in diverse mammals.
Laukaitis CM, Heger A, Blakley TD, Munclinger P, Ponting CP, Karn RC. BMC Evol Biol. 2008 Feb 12; 8:46. Epub 2008 Feb 12.
Crystallization and preliminary crystallographic data of a Fel d 1 (1+2) construct corresponding to the major allergen from cat. [Acta Crystallogr Sect F Struct...]
Crystallization and preliminary crystallographic data of a Fel d 1 (1+2) construct corresponding to the major allergen from cat.
Kaiser L, Grönlund H, van Hage-Hamsten M, Achour A. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Feb 1; 61(Pt 2):232-4. Epub 2005 Feb 1.

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Amino acid sequence of Fel dI, the major allergen of the domestic cat: protein s...
Amino acid sequence of Fel dI, the major allergen of the domestic cat: protein sequence analysis and cDNA cloning.
Proc Natl Acad Sci U S A. 1991 Nov 1 ;88(21):9690-4.

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