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JACC Cardiovasc Interv. 2009 Mar;2(3):215-21. doi: 10.1016/j.jcin.2008.11.011.

N-acetylcysteine-enhanced contrast provides cardiorenal protection.

Author information

  • 1Division of Cardiology, University of Vermont College of Medicine, Burlington, Vermont 05401, USA. markus.meyer@vtmednet.org

Abstract

OBJECTIVES:

We sought to evaluate the cardiac and renal effects of an N-acetylcysteine (NAC)-enhanced intracoronary radiographic contrast agent.

BACKGROUND:

Recent studies suggest that high-dose NAC provides better protection from contrast-induced nephropathy, and the antioxidant properties of NAC may also provide cardiac protection. The use of angiographic contrast agents as a drug delivery vehicle for cardiorenal protection effects has not been investigated.

METHODS:

In a pig model of prolonged cardiac ischemia-reperfusion, NAC-enhanced contrast medium was tested and compared with iopamidol contrast only. Myocardium and renal function were assessed after 24 h.

RESULTS:

There was no significant difference in the area-at-risk for myocardial infarction (MI) between contrast only and NAC-enhanced contrast medium. In contrast, MI size was about 40% smaller in NAC-enhanced contrast medium-treated animals. These findings were associated with a significant difference in MI morphology. MIs in the NAC-enhanced contrast medium group had a mottled appearance, whereas in the contrast only group they were homogeneous and had a discrete border zone. These differences could explain a higher incidence of periprocedural ventricular arrhythmias in the NAC-enhanced contrast medium group. Histopathological analysis of the myocardium revealed a reduction in programmed cell death by NAC-enhanced contrast medium that may explain the increase in ischemia tolerance. Last, NAC-enhanced contrast medium administration blunted the rise in serum creatinine levels by about 60% and protected from renotubular apotosis.

CONCLUSIONS:

NAC-enhanced contrast medium reduces MI size and protects renal function in a pig model of ischemia and reperfusion.

PMID:
19463428
[PubMed - indexed for MEDLINE]
PMCID:
PMC2819370
Free PMC Article
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