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Nature. 2009 May 21;459(7245):356-63. doi: 10.1038/nature08144.

The structure and function of G-protein-coupled receptors.

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  • 1Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Palo Alto, California 94305, USA.

Abstract

G-protein-coupled receptors (GPCRs) mediate most of our physiological responses to hormones, neurotransmitters and environmental stimulants, and so have great potential as therapeutic targets for a broad spectrum of diseases. They are also fascinating molecules from the perspective of membrane-protein structure and biology. Great progress has been made over the past three decades in understanding diverse GPCRs, from pharmacology to functional characterization in vivo. Recent high-resolution structural studies have provided insights into the molecular mechanisms of GPCR activation and constitutive activity.

PMID:
19458711
[PubMed - indexed for MEDLINE]
PMCID:
PMC3967846
Free PMC Article
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