Autophagy. 2009 Aug;5(6):847-9. Epub 2009 Aug 23.

Autophagy is required for extension of yeast chronological life span by rapamycin.

Alvers AL, Wood MS, Hu D, Kaywell AC, Dunn WA Jr, Aris JP.

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Department of Cell Biology, Duke University Medical Center, Durham, NC, USA.

Abstract

Rapamycin is an antibiotic that stimulates autophagy in a wide variety of eukaryotes, including the budding yeast Saccharomyces cerevisiae. Low concentrations of rapamycin extend yeast chronological life span (CLS). We have recently shown that autophagy is required for chronological longevity in yeast, which is attributable in part to a role for autophagy in amino acid homeostasis. We report herein that low concentrations of rapamycin stimulate macroautophagy during chronological aging and extend CLS.

PMID:: 19458476; [PubMed - indexed for MEDLINE]

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