Gastroenterology. 2009 May;136(6):1863-73. Epub 2009 May 7.

Helicobacter pylori in health and disease.

Source

Department of Medicine, Vanderbilt University School of Medicine and Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee 37232, USA. timothy.L.cover@vanderbilt.edu

Abstract

Helicobacter pylori is highly adapted for colonization of the human stomach and is present in about half of the human population. When present, H pylori is usually the numerically dominant gastric microorganism. H pylori typically does not cause any adverse effects, but it is associated with an increased risk of noncardia gastric adenocarcinoma, gastric lymphoma, and peptic ulcer. Disorders such as esophageal diseases and childhood-onset asthma were recently reported to occur more frequently in individuals who lack H pylori than in H pylori-positive persons. In this review, we discuss biologic factors that allow H pylori to colonize the human stomach, mechanisms by which H pylori increases the risk of peptic ulcer disease and noncardia gastric adenocarcinoma, and potential benefits that H pylori might confer to humans.

PMID:: 19457415; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Grant Support

Publication Types

MeSH Terms

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Stomach Disorders - MedlinePlus Health Information

Supplemental Content

Related citations

Review Immune responses to Helicobacter pylori colonization: mechanisms and clinical outcomes. [Clin Sci (Lond). 2006]
Review Immune responses to Helicobacter pylori colonization: mechanisms and clinical outcomes.
Portal-Celhay C, Perez-Perez GI. Clin Sci (Lond). 2006 Mar; 110(3):305-14.
Review [Epidemiology and pathogenesis of Helicobacter pylori infection]. [Wien Med Wochenschr. 2002]
Review [Epidemiology and pathogenesis of Helicobacter pylori infection].
Wolle K, Leodolter A, Malfertheiner P. Wien Med Wochenschr. 2002; 152(5-6):117-22.
Helicobacter pylori: consensus and controversy. [Clin Infect Dis. 2002]
Helicobacter pylori: consensus and controversy.
Passaro DJ, Chosy EJ, Parsonnet J. Clin Infect Dis. 2002 Aug 1; 35(3):298-304. Epub 2002 Jul 8.
Review Helicobacter pylori disease in childhood. [Clin Pediatr (Phila). 1996]
Review Helicobacter pylori disease in childhood.
Blecker U. Clin Pediatr (Phila). 1996 Apr; 35(4):175-83.
Review Helicobacter pylori persistence: an overview of interactions between H. pylori and host immune defenses. [Clin Microbiol Rev. 2006]
Review Helicobacter pylori persistence: an overview of interactions between H. pylori and host immune defenses.
Algood HM, Cover TL. Clin Microbiol Rev. 2006 Oct; 19(4):597-613.

See reviews... See all...

Cited by 25 PubMed Central articles

Helicobacter pylori interferes with an embryonic stem cell micro RNA cluster to block cell cycle progression. [Silence. 2011]
Helicobacter pylori interferes with an embryonic stem cell micro RNA cluster to block cell cycle progression.
Belair C, Baud J, Chabas S, Sharma CM, Vogel J, Staedel C, Darfeuille F. Silence. 2011 Oct 25; 2(1):7. Epub 2011 Oct 25.
Helicobacter pylori exploits a unique repertoire of type IV secretion system components for pilus assembly at the bacteria-host cell interface. [PLoS Pathog. 2011]
Helicobacter pylori exploits a unique repertoire of type IV secretion system components for pilus assembly at the bacteria-host cell interface.
Shaffer CL, Gaddy JA, Loh JT, Johnson EM, Hill S, Hennig EE, McClain MS, McDonald WH, Cover TL. PLoS Pathog. 2011 Sep; 7(9):e1002237. Epub 2011 Sep 1.
What is the difference between Helicobacter pylori-associated dyspepsia and functional dyspepsia? [J Neurogastroenterol Motil. 2011]
What is the difference between Helicobacter pylori-associated dyspepsia and functional dyspepsia?
Suzuki H, Matsuzaki J, Hibi T. J Neurogastroenterol Motil. 2011 Apr; 17(2):124-30. Epub 2011 Apr 27.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Helicobacter pylori in health and disease.
Helicobacter pylori in health and disease.
Gastroenterology. 2009 May ;136(6):1863-73. Epub 2009 May 7 .

PubMed
Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel c...
Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumors.
Int J Cancer. 2009 Sep 15 ;125(6):1243-9.

PubMed
Human Merkel cell polyomavirus infection II. MCV is a common human infection tha...
Human Merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassays.
Int J Cancer. 2009 Sep 15 ;125(6):1250-6.

PubMed
Non-steroidal anti-inflammatory drugs and risk of gastric and oesophageal adenoc...
Non-steroidal anti-inflammatory drugs and risk of gastric and oesophageal adenocarcinomas: results from a cohort study and a meta-analysis.
Br J Cancer. 2009 Feb 10 ;100(3):551-7. Epub 2009 Jan 20 .

PubMed
Extracorporeal pumpless interventional lung assist in clinical practice: determi...
Extracorporeal pumpless interventional lung assist in clinical practice: determinants of efficacy.
Eur Respir J. 2009 Mar ;33(3):551-8. Epub 2008 Nov 14 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: