Format

Send to:

Choose Destination
See comment in PubMed Commons below
Kidney Int. 2009 Jul;76(2):149-68. doi: 10.1038/ki.2009.128. Epub 2009 May 20.

Autosomal dominant polycystic kidney disease: the last 3 years.

Author information

  • 1Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA. torres.vicente@mayo.edu

Abstract

Autosomal dominant polycystic kidney disease is the most prevalent, potentially lethal monogenic disorder. It has large inter- and intra-familial variability explained to a large extent by its genetic heterogeneity and modifier genes. An increased understanding of its underlying genetic, molecular, and cellular mechanisms and a better appreciation of its progression and systemic manifestations have laid out the foundation for the development of clinical trials and potentially effective therapies. The purpose of this review is to update the core of knowledge in this area with recent publications that have appeared during 2006-2009.

PMID:
19455193
[PubMed - indexed for MEDLINE]
PMCID:
PMC2812475
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Write to the Help Desk