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Nat Rev Neurosci. 2009 Jun;10(6):446-57. doi: 10.1038/nrn2649.

Psychobiology and molecular genetics of resilience.

Author information

  • 1Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA. adriana.feder@mssm.edu

Abstract

Every individual experiences stressful life events. In some cases acute or chronic stress leads to depression and other psychiatric disorders, but most people are resilient to such effects. Recent research has begun to identify the environmental, genetic, epigenetic and neural mechanisms that underlie resilience, and has shown that resilience is mediated by adaptive changes in several neural circuits involving numerous neurotransmitter and molecular pathways. These changes shape the functioning of the neural circuits that regulate reward, fear, emotion reactivity and social behaviour, which together are thought to mediate successful coping with stress.

PMID:
19455174
[PubMed - indexed for MEDLINE]
PMCID:
PMC2833107
Free PMC Article
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