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J Phys Chem B. 2009 Jun 11;113(23):8137-41. doi: 10.1021/jp900379w.

Ex vivo diagnosis of lung cancer using a Raman miniprobe.

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  • 1Respiratory Medicine Research Group, Centre for Infection and Immunity, Microbiology Building, Queens University Belfast, Grosvenor Road, Belfast, BT12 6BN, United Kingdom.


Lung cancer is the most common cause of cancer death. The conventional method of confirming the diagnosis is bronchoscopy, inspecting the airways of the patient with a fiber optic endoscope. A number of studies have shown that Raman spectroscopy can diagnose lung cancer in vitro. In this study, Raman spectra were obtained from ex vivo normal and malignant lung tissue using a minifiber optic Raman probe suitable for insertion into the working channel of a bronchoscope. Shifted subtracted Raman spectroscopy was used to reduce the fluorescence from the lung tissue. Using principal component analysis with a leave-one-out analysis, the tissues were classified accurately. This novel technique has the potential to obtain Raman spectra from tumors from patients with lung cancer in vivo.

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