Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Phys Chem B. 2009 Jun 11;113(23):8137-41. doi: 10.1021/jp900379w.

Ex vivo diagnosis of lung cancer using a Raman miniprobe.

Author information

  • 1Respiratory Medicine Research Group, Centre for Infection and Immunity, Microbiology Building, Queens University Belfast, Grosvenor Road, Belfast, BT12 6BN, United Kingdom. n.d.magee@qub.ac.uk

Abstract

Lung cancer is the most common cause of cancer death. The conventional method of confirming the diagnosis is bronchoscopy, inspecting the airways of the patient with a fiber optic endoscope. A number of studies have shown that Raman spectroscopy can diagnose lung cancer in vitro. In this study, Raman spectra were obtained from ex vivo normal and malignant lung tissue using a minifiber optic Raman probe suitable for insertion into the working channel of a bronchoscope. Shifted subtracted Raman spectroscopy was used to reduce the fluorescence from the lung tissue. Using principal component analysis with a leave-one-out analysis, the tissues were classified accurately. This novel technique has the potential to obtain Raman spectra from tumors from patients with lung cancer in vivo.

PMID:
19453143
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for American Chemical Society
    Loading ...
    Write to the Help Desk