Mol Cell. 2009 May 15;34(3):257-8.

Of elections and cell-death decisions.

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Signaling Systems Laboratory, Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093, USA.

Abstract

A new study in the journal Nature (Spencer et al., 2009) argues that cell-to-cell variation in the decision to undergo apoptosis is not due to genetic, epigenetic, or cell-cycle differences, nor due to random molecular noise, but instead is determined by differences in protein abundances.

Comment on

19363473. Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis.; Nature. 2009 Apr 12. [Epub ahead of print].

PMID:: 19450524; [PubMed - indexed for MEDLINE]

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