Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Nat Med. 2009 Jun;15(6):623-5. doi: 10.1038/nm.1959.

Netting neutrophils in autoimmune small-vessel vasculitis.

Author information

  • 1Department of Neuroimmunology,Max-Planck-Institute of Neurobiology, Martinsried, Germany. kai.kessenbrock@ucsf.edu

Abstract

Small-vessel vasculitis (SVV) is a chronic autoinflammatory condition linked to antineutrophil cytoplasm autoantibodies (ANCAs). Here we show that chromatin fibers, so-called neutrophil extracellular traps (NETs), are released by ANCA-stimulated neutrophils and contain the targeted autoantigens proteinase-3 (PR3) and myeloperoxidase (MPO). Deposition of NETs in inflamed kidneys and circulating MPO-DNA complexes suggest that NET formation triggers vasculitis and promotes the autoimmune response against neutrophil components in individuals with SVV.

Comment in

PMID:
19448636
[PubMed - indexed for MEDLINE]
PMCID:
PMC2760083
Free PMC Article

Images from this publication.See all images (2)Free text

Figure 1
Figure 2
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Write to the Help Desk