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Nat Genet. 2009 Jun;41(6):648-50. doi: 10.1038/ng.386. Epub 2009 May 17.

Meta-analysis of genome-wide association data identifies two loci influencing age at menarche.

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  • 1Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK.

Abstract

We conducted a meta-analysis of genome-wide association data to detect genes influencing age at menarche in 17,510 women. The strongest signal was at 9q31.2 (P = 1.7 × 10(-9)), where the nearest genes include TMEM38B, FKTN, FSD1L, TAL2 and ZNF462. The next best signal was near the LIN28B gene (rs7759938; P = 7.0 × 10(-9)), which also influences adult height. We provide the first evidence for common genetic variants influencing female sexual maturation.

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PMID:
19448620
[PubMed - indexed for MEDLINE]
PMCID:
PMC2942986
Free PMC Article

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