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Nat Genet. 2009 Jun;41(6):645-7. doi: 10.1038/ng.387. Epub 2009 May 17.

Loci at chromosomes 13, 19 and 20 influence age at natural menopause.

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  • 1Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.

Abstract

We conducted a genome-wide association study for age at natural menopause in 2,979 European women and identified six SNPs in three loci associated with age at natural menopause: chromosome 19q13.4 (rs1172822; -0.4 year per T allele (39%); P = 6.3 × 10(-11)), chromosome 20p12.3 (rs236114; +0.5 year per A allele (21%); P = 9.7 × 10(-11)) and chromosome 13q34 (rs7333181; +0.5 year per A allele (12%); P = 2.5 × 10(-8)). These common genetic variants regulate timing of ovarian aging, an important risk factor for breast cancer, osteoporosis and cardiovascular disease.

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PMID:
19448619
[PubMed - indexed for MEDLINE]
PMCID:
PMC3000545
Free PMC Article
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