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Appl Environ Microbiol. 2009 Jul;75(14):4909-12. doi: 10.1128/AEM.02478-08. Epub 2009 May 15.

Identification of a polyketide synthase coding sequence specific for anatoxin-a-producing Oscillatoria cyanobacteria.

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  • 1Unité des Cyanobactéries (URA CNRS 2172), Institut Pasteur, 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France.


We report the identification of a sequence from the genome of Oscillatoria sp. strain PCC 6506 coding for a polyketide synthase. Using 50 axenic cyanobacteria, we found this sequence only in the genomes of Oscillatoria strains producing anatoxin-a or homoanatoxin-a, indicating its likely involvement in the biosynthesis of these toxins.

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