Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Trends Immunol. 2009 Jun;30(6):277-85. doi: 10.1016/j.it.2009.03.008. Epub 2009 May 15.

New insights into the regulation of human B-cell differentiation.

Author information

  • 1Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, The Netherlands.

Abstract

B lymphocytes provide the cellular basis of the humoral immune response. All stages of this process, from B-cell activation to formation of germinal centers and differentiation into memory B cells or plasma cells, are influenced by extrinsic signals and controlled by transcriptional regulation. Compared to naïve B cells, memory B cells display a distinct expression profile, which allows for their rapid secondary responses. Indisputably, many B-cell malignancies result from aberrations in the circuitry controlling B-cell function, particularly during the germinal centre (GC) reaction. Here, we review new insights into memory B-cell subtypes, recent literature on transcription factors regulating human B-cell differentiation and further evidence for B-cell lymphomagenesis emanating from errors during GC cell reactions.

PMID:
19447676
[PubMed - indexed for MEDLINE]
PMCID:
PMC2792751
Free PMC Article

Images from this publication.See all images (2)Free text

Figure 1
Figure 2
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk