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Vaccine. 2009 May 21;27(24):3209-12. doi: 10.1016/j.vaccine.2009.03.037. Epub 2009 Apr 7.

Immunogenicity and safety of diphtheria-tetanus vaccine in pre-adolescent and adolescent South Koreans.

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  • 1Department of Pediatrics, The Catholic University of Korea, Seoul, Republic of Korea.


This study was conducted to compare the immunogenicity and safety of diphtheria-tetanus (Td) vaccine between pre-adolescents aged 11-12 years and adolescents aged 13-18 years. A total of 277 subjects (132 pre-adolescents and 145 adolescents) participated. After vaccination, all subjects (100%) in both groups exhibited seroprotective antibody levels (> or =0.1I U/mL) against diphtheria or tetanus toxoids. Although local adverse events following vaccination were more frequently observed in the pre-adolescent group than in the adolescent group (p=0.006), these events resolved within 7 days. Our study shows Td vaccination at age 11-12 years to be immunogenic and tolerable.

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