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    J Nat Prod. 2009 Jun;72(6):1191-4.

    Antibacterial diterpenes from Plectranthus ernstii.

    Stavri M, Paton A, Skelton BW, Gibbons S.

    Source

    Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, London, UK.

    Abstract

    Three new diterpenoids including two pimaranes (1 and 2) and a labdane (3) were isolated from the whole herb of Plectranthus ernstii. The structures of these compounds were determined as rel-15(zeta),16-epoxy-7alpha-hydroxypimar-8,14-ene (1) and rel-15(zeta),16-epoxy-7-oxopimar-8,14-ene (2), and compound 3 was elucidated as 1R,11S-dihydroxy-8R,13R-epoxylabd-14-ene on the basis of single-crystal X-ray structural analysis. Compound 1 exhibited moderate antistaphylococcal activity against a range of multidrug-resistant (MDR) and methicillin-resistant (MRSA) strains of Staphylococcus aureus with a minimum inhibitory concentration (MIC) of 32 microg/mL. All three diterpenes exhibited antimycobacterial activity against three strains of rapidly growing mycobacteria with MIC values ranging from 8 to 128 microg/mL.

    PMID:
    19445517
    [PubMed - indexed for MEDLINE]

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