J Hypertens. 2009 Jul;27(7):1341-9.

Is kidney ischemia the central mechanism in parallel activation of the renin and sympathetic system?

Siddiqi L, Joles JA, Grassi G, Blankestijn PJ.

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Department of Nephrology and Hypertension, University Medical Center, Utrecht, The Netherlands.

Abstract

In chronic kidney disease simultaneous activation of the renin-angiotensin and sympathetic systems occurs. Kidney ischemia seems to play a key role in the pathogenesis. This review firstly summarizes experimental and clinical evidence in chronic kidney disease supporting this idea and addresses the possibility that this mechanism is also relevant in some other disease conditions.

PMID:: 19444143; [PubMed - indexed for MEDLINE]

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Cited by 2 PubMed Central articles

Evidence and consequences of the central role of the kidneys in the pathophysiology of sympathetic hyperactivity. [Front Physiol. 2012]
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