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Science. 2009 Jun 19;324(5934):1572-6. doi: 10.1126/science.1175194. Epub 2009 May 14.

A vital role for interleukin-21 in the control of a chronic viral infection.

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  • 1Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294-2170, USA.

Abstract

Understanding the factors that regulate the induction, quality, and longevity of antiviral T cell responses is essential for devising rational strategies to prevent or combat infections. In this study, we show that interleukin-21 (IL-21), likely produced by CD4+ T cells, directly influences the generation of polyfunctional CD8+ T cells and that the number of CD4+ T cells that produce IL-21 differs markedly between acute and chronic infections. IL-21 regulates the development of CD8+ T cell exhaustion and the ability to contain chronic lymphocytic choriomeningitis virus infection. Thus, IL-21 serves as a critical helper factor that shapes the functional quality of antiviral CD8+ T cells and is required for viral control.

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PMID:
19443735
[PubMed - indexed for MEDLINE]
PMCID:
PMC2736049
Free PMC Article

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