Odds ratio of association of imaging parameters with baseline laboratory and imaging features. Plotted are the log odds ratio values with 95% confidence interval values for 5 imaging parameters (PET-FL, FDG-avid focal lesion number; MRI-FL, MRI-defined focal lesion number, MBS-OL, metastatic bone survey-defined osteolytic lesion number; SUV-FL, maximum standardized uptake values at bone marrow focal lesion sites; CT-OL, computed tomography–defined osteolytic lesion number). Significant correlations were observed for most imaging parameters with B2M, LDH, and several GEP-derived parameters such as high-risk, LB disease and proliferation (PR) subgroups, and proliferation index (PI).

Overall survival and event-free survival and cumulative incidence of complete or near-complete response. (A-E) Overall survival and event-free survival outcomes according to imaging parameters (MBS-OL, MRI-FL, PET-FL, SUV-FL, EMD [cut-points based on tertile distributions and collapsing categories with similar outcomes]): Both overall and event-free survival durations were significantly shorter in the presence of EMD detected on PET examination (A), higher osteolytic lesion number enumerated on metastatic bone survey (MBS-OL; B), and higher focal lesion number on PET (PET-FL; D). Magnetic resonance imaging–defined focal lesions (MRI-FL) conferred inferior event-free survival and a trend toward inferior overall survival (C). Among the overall favorable GEP-defined low-risk group, PET-FL more than 3 identified a subset with inferior outcomes (E). (F-G) Survival outcomes according to complete FDG suppression (100%) before first transplantation: Complete FDG suppression at the end of 2 induction chemotherapy cycles before first transplantation conferred favorable overall and event-free survival (F), which was particularly important for the subset of patients presenting with GEP-defined high-risk features (G). (H) Time course to complete or near-complete response (CR, n-CR; defined by myeloma-protein and bone marrow criteria) and to imaging-defined complete response (resolution of focal lesions on MRI [MRI-CR] and PET [PET-CR], normalization of bone marrow intensity to hypointensity status in patients without MRI-FL): PET-CR status was attained more rapidly than clinical CR or n-CR and especially MRI-CR status among patients presenting with MRI-FL.

Untreated myeloma patient with time-concordant MBS, MRI, and FDG-PET/CT studies. Baseline imaging studies (top row) showed no osteolysis on MBS (top left), several foci on STIR-weighted MRI images with the largest in the left ischium (top middle), and 2 foci on FDG-PET/CT imaging (top right) with the largest again in the left ischium with a maximum SUV of 4.1. The patient was in near-complete remission 168 days later, with a significant decrease in focal activity in the left ischial lesion on PET (bottom right).