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J Infect. 2009 Jun;58(6):425-32. doi: 10.1016/j.jinf.2009.04.004. Epub 2009 Apr 18.

Long pentraxin PTX3 is associated with mortality and disease severity in severe Leptospirosis.

Author information

  • 1Slotervaart Hospital, Department of Internal Medicine (9B), Louwesweg 6, 1066 EC, Amsterdam, The Netherlands. jfpwagenaar@hotmail.com

Abstract

OBJECTIVE:

To evaluate the long pentraxin PTX3 in patients with severe leptospirosis and to compare the results with the widely used short pentraxin C-reactive protein and the pro-inflammatory cytokines IL-6 and IL-8.

METHODS:

This observational cohort study was carried out in Semarang, Indonesia, where leptospirosis is endemic and mortality is high. Consecutive patients with severe leptospirosis were sampled on admission and during follow-up.

RESULTS:

A total number of 52 patients entered the study, the mortality was 27%. Severe leptospirosis patient yielded elevated plasma PTX3 levels. PTX3 correlated with IL-8 and to a lesser extent with CRP and IL-6 levels. High levels of PTX3, IL-6 and IL-8 were associated with mortality (OR 5.6, 95%CI: 1.2-26; OR 3.2, 95%CI: 1.2-8.1; OR 6.5, 95%CI: 1.5-28). Moreover, PTX3 levels were associated with disease severity (OR 9.5; 95%CI: 2.9-45). This association was unique, since none of the other markers showed this relation. C-reactive protein was not able to differentiate the severe from the severest cases.

CONCLUSIONS:

The long pentraxin PTX3 is elevated in patients with severe leptospirosis and is associated with fatal disease and disease severity. PTX3 may be used as a marker to monitor disease severity in severe leptospirosis or predict outcome.

PMID:
19443038
[PubMed - indexed for MEDLINE]
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