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    Neurosci Lett. 2009 Jul 17;458(2):57-9. Epub 2009 Apr 11.

    18-Methoxycoronaridine blocks acquisition but enhances reinstatement of a cocaine place preference.

    McCallum SE, Glick SD.

    Source

    Albany Medical College, Albany, NY, USA. mccalls@mail.amc.edu

    Abstract

    The iboga alkaloid congener, 18-methoxycoronaridine (18-MC), decreases self-administration of multiple drugs of abuse. Here, in a biased procedure, we investigated whether 18-MC would have a similar effect on the acquisition, expression and reinstatement of a cocaine conditioned place preference (CPP) in male Sprague-Dawley rats. While 18-MC attenuated acquisition of a cocaine CPP, it had no effect on CPP expression, and enhanced the reinstatement of cocaine CPP following extinction. Our results are consistent with those obtained using ibogaine, but reinforce the notion that acquisition, expression and reinstatement of a CPP likely involve separate mechanisms.

    PMID:
    19442876
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2688769
    Free PMC Article

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