J Fam Pract. 2009 May;58(5):281a-b.

Clinical inquiries. What's the most practical way to rule out adrenal insufficiency?

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University of Minnesota/St. Cloud Hospital Family Medicine Residency, St. Cloud, MN USA.

Abstract

A morning serum cortisol level >13 mcg/dL reliably rules out adrenal insufficiency, and the test is easy and safe to perform. Because of low specificity, patients with a level of < or =13 mcg/dL need further evaluation with the cosyntropin stimulation test (CST). The 250 mcg CST requires intravenous (IV) or intramuscular (IM) administration of cosyntropin and multiple blood draws; a normal response reliably rules out primary adrenal insufficiency and moderately decreases the likelihood of secondary adrenal insufficiency. The 1 mcg CST has better diagnostic discrimination, but requires an extra step to dilute the cosyntropin.

PMID:: 19442385; [PubMed - indexed for MEDLINE]

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