Source
Department of Psychiatry, The University of Iowa Hospital and Clinics, 200 Hawkins Drive, Iowa City, IA 52242-1009, USA. hristina-koleva@uiowa.edu
Abstract
BACKGROUND:
Edema associated with quetiapine has been described in only one case report to date and represents a potentially serious adverse reaction.
METHODS:
We present a case series of 3 patients who developed bilateral leg edema following initiation of quetiapine.
RESULTS:
One of these patients had a recurrence of edema with subsequent rechallenge. Another patient developed quetiapine-induced edema following a prior episode of olanzapine-induced edema. All 3 cases present a compelling temporal relationship between the drug challenge and the adverse event.
CONCLUSION:
Prompt recognition and intervention with discontinuation of the offending agent is important for this potentially serious, seemingly idiosyncratic vascular complication.