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Hypertens Pregnancy. 2009 May;28(2):201-11. doi: 10.1080/10641950802601187.

CA-125 and CRP are elevated in preeclampsia.

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  • 1Obstetric and Gynecology Department, Gaziantep University Faculty of Medicine, Gaziantep/Turkey.



To determine the relationship between the cancer antigen-125 (CA-125) and C-reactive protein (CRP) with preeclampsia and eclampsia.


The study group included 54 preeclamptic/eclamptic women, and 56 healthy pregnant women served as the control group. Mean arterial pressure (MAP) and albumin levels were used to monitor the severity of disease. CRP and CA-125 levels were determined. The cut-offs for CRP and CA-125 were 5 mg/L and 35 IU/ml. The t-test, Pearson correlation and ANOVA were used for statistical analysis. Values of p < 0.05 were considered to be significant.


CRP and CA-125 parameters were significantly higher in the study group (p < 0.001), and were significantly higher in severe preeclampsia and eclampsia groups than in mild preeclampsia (p < 0.001). Significant correlations were found between CRP/MAP, CRP/albumin, CA-125/MAP and CA-125/albumin (p < 0.001).


CRP and CA-125 are elevating markers in preeclampsia.

[PubMed - indexed for MEDLINE]
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