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Vasc Health Risk Manag. 2009;5(1):89-95. Epub 2009 Apr 8.

The independent relationship between triglycerides and coronary heart disease.

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  • 1SCRIBCO, Blue Bell, PA, USA.

Abstract

AIMS:

The aim was to review epidemiologic studies to reassess whether serum levels of triglycerides should be considered independently of high-density lipoprotein-cholesterol (HDL-C) as a predictor of coronary heart disease (CHD).

METHODS AND RESULTS:

We systematically reviewed population-based cohort studies in which baseline serum levels of triglycerides and HDL-C were included as explanatory variables in multivariate analyses with the development of CHD (coronary events or coronary death) as dependent variable. A total of 32 unique reports describing 38 cohorts were included. The independent association between elevated triglycerides and risk of CHD was statistically significant in 16 of 30 populations without pre-existing CHD. Among populations with diabetes mellitus or pre-existing CHD, or the elderly, triglycerides were not significantly independently associated with CHD in any of 8 cohorts. Triglycerides and HDL-C were mutually exclusive predictors of coronary events in 12 of 20 analyses of patients without pre-existing CHD.

CONCLUSIONS:

Epidemiologic studies provide evidence of an association between triglycerides and the development of primary CHD independently of HDL-C. Evidence of an inverse relationship between triglycerides and HDL-C suggests that both should be considered in CHD risk estimation and as targets for intervention.

KEYWORDS:

coronary heart disease; high-density lipoprotein-cholesterol; hypercholesterolemia; low-density lipoprotein-cholesterol; triglycerides

PMID:
19436658
PMCID:
PMC2672447
[PubMed - indexed for MEDLINE]
Free PMC Article
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